By Derek Crowther (auth.), Professor Derek Crowther (eds.)
A good deal of recent info has been got up to now 4 years, and this monograph offers a transparent and good reviewed replace on biochemical mechanisms and the result of vital new medical reviews utilizing the interferons. stories contain what's almost immediately identified concerning the biosynthesis, physiological function and mechanisms of motion of the interferons (alpha, beta, gamma). New biochemical details on interferon-receptor interactions and signalling pathways is supplied. The pharmacokinetic concerns in treating leukemia, lymphoma, myeloma, neuroendocrine tumors and different good tumors are reviewed with specific emphasis on experiences of adjuvant chemotherapy in malignancies of the immune system.
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Extra info for Interferons: Mechanisms of Action and Role in Cancer Therapy
The study thus attempts to answer 2 separate questions: first, does the addition of interferon to chlorambucil as initial therapy improve the response rate, and second, does the use of interferon as 'maintenance' therapy prolong remission duration? A similar study is being conducted in Italy . The preliminary results of both can be summarised as follows: the addition of interferon to chlorambucil has not improved the respqnse rate or the complete response rate. As expected, the combination is associated with a greater degree of myelosuppression than chlorambucil alone.
Al: Maintenance chlorambucil after CVP in the management of advanced stage, low grade histologic type non-Hodgkin's lymphoma. Cancer 1988 (6113):441-447 Paryani SB, Hoppe RT, Cox RS et al: Analysis of non-Hodgkin's lymphomas with nodular and favourable histologies, stages I and II. Cancer 1983 (52):2300 Richards MA, Gregory WM, Hall PA et al: Management of localised non-Hodgkin's lymphoma: the experience at St Bartholomew's Hospital 19721985. Haematol Oncol 1989 (7):1-18 McKelvey EM, Gottilev JA, Wilson HE et al: Hydroxydaunomycin (Adriamycin) combination chemotherapy in malignant lymphoma.
Pts. Follicular lymphoma Follicular lymphoma is an enigmatic disease: on the one hand, the majority of patients respond to treatment, be it chemotherapy or irradiation, indeed they may respond repeatedly, and yet the disease remains incurable, the inexorable pattern of relapse making death from lymphoma virtually inevitable. A new approach is therefore urgently needed. Ref. Non-recombinant IFNs IFN-a IFN-a IFN-a 3 4 3 6 8 18   [11 ]     Recombinant IFNs IFN-aA IFN-aA· IFN-aA IFN-aA· 4 13 17 9 24 15 30 TOTAL 53 120 6 • previously untreated patients 36 A.
Interferons: Mechanisms of Action and Role in Cancer Therapy by Derek Crowther (auth.), Professor Derek Crowther (eds.)