By Larry Davis
Plane quantity 141 motion sequence. Illustrated all through with b/w photos. There are pages with colour images, a variety of multi-view line drawings.
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Following binding to the intracellular GC receptor complex, the ligand/receptor/heat shock protein complex translocates into the nucleus and interacts with both transcription factors (like NFKB) and DNA (via GC responsive elements in various promoter regions) mediating transactivating or transrepressing mechanisms (Table 1). Both pathways mediate the anti-inflammatory properties of GC, whereas the side effects are mainly induced via the transactivating mechanisms. Recent results (this volume) suggest that it might be possible to separate the transactivating and transrepressing effects of GC in order to promote anti-inflammatory properties in absence of most of the side effects.
The expression of many adhesion molecules on endothelial cells is induced by cytokines and corticosteroids may lead indirectly to a reduced expression via their inhibitory effects on cytokines, such as IL-l~ and tumour necrosis factor (TNF)-a. Corticosteroids may also have a direct inhibitory effect on the expression of adhesion molecules, such as intercellular adhesion molecule (ICAM)-1 and E-selectin at the level of gene transcription. ICAM-1 and vascular cell adhesion molecule (VCAM)-1 expression in bronchial epithelial cell lines and monocytes is inhibited by corticosteroids (Atsuta et al.
1996). Inhaled corticosteroids inhibit the increased expression of many inflammatory proteins in airway epithelial cells. An example is iNOS, which has an increased expression in airway epithelial and inflammatory cells in asthma and is reduced by inhaled corticosteroids (Saleh et al. 1998). J. Barnes This is reflected by a reduction in the elevated levels of exhaled NO in asthma after inhaled corticosteroids (Kharitonov et a!. 9 Mucus Secretion Corticosteroids inhibit mucus secretion in airways and this may be a direct action of corticosteroids on submucosal gland cells.
Boeing P-12 / F-4B in action by Larry Davis