By Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)
This ebook, written through prime authors within the box, is the 1st to accommodate all features of cytokine antibodies, from attempt technique and standardization to organic results and features. It encompasses antibodies prompted by way of cytokines used therapeutically and antiviral antibodies. to appreciate the biology, the consequences of cytokine antibodies in experimental animal versions and sufferers also are mentioned. The ebook is meant for researchers of cytokine biology, pharmaceutical businesses constructing cytokines and cytokine antibodies as treatments, and clinicians drawn to modulating the immune procedure as therapy.
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Extra info for Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals
29: 489-492. , Monti, E. and Balsari, A. 1993. The detection and biological activity of human antibodies to IL-2 in normal donors. Scand. J. Immunol. 38: 472-476. , Diamant, M. and Bendtzen, K. 1991. Anti-interleukin-6 antibodies in normal human serum. Scand. J. Immunol. 33: 777-781. 17. 18. 19. 20. 21. , Yuhara, T, Akama, T, Yamane, K. and Kashiwagi, H. 1992. Antiinterleukin-6 autoantibodies in rheumatic diseases: increased frequency in the sera of patients with systemic sclerosis. Arthritis Rheum.
Additionally, bioassays detect "free" antibodies only which may represent only a limited fraction of the total number of circulating neutralizing antibodies. Cytokine capture assays detect both neutralizing and binding antibodies but are also limited to 'free' antibodies. Most of the antibodies may occur in complexed form with either anti-idiotypic antibodies or their respective ligands, thereby escaping detection in the current assays. A role of ACAs in controlling cytokine production was suggested by experiments in mice showing that the administration of neutralizing anti-IL-6 monoclonal antibodies to mice resulted in a dramatic increase in the amount of IL-6 bioactivitiy in the circulation.
We measured the avidity of human antibodies, and of mouse and rabbit antibodies to IFN-, proteins absorbed on the wells of 96-well microtitre plates by RIA. 1). Affinity purification. Human IFN-, antibodies were purified from human Ig preparations taken from healthy subjects by a one-step chromatographic procedure using a recombinant IPN-,-coupled Sepharose CL4B affinity column . The antibodies to lPN-, were eluted from the column by 3 different methods with no loss of immunological activity.
Antibodies in Cytokines: The concerted action on the antigenicity of rDNA derived pharmaceuticals by Kjell Öberg, Gunnar Alm (auth.), Huub Schellekens (eds.)